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Treating Waldenstrom Macroglobulinemia

If you’ve been diagnosed with Waldenstrom macroglobulinemia, your treatment team will discuss your options with you. It’s important to weigh the benefits of each treatment option against the possible risks and side effects.

How is Waldenstrom macroglobulinemia treated?

If treatment is needed for Waldenstrom macroglobulinemia (WM), several types can be used:

Common treatment approaches

Not everyone with WM needs to be treated right away. People who don’t have serious or bothersome?symptoms?can often be watched closely, and then treated later if needed.?

The 2 main ways to treat WM are chemotherapy and different types of biological therapy (immunotherapy). One or both of these types of treatments might be used.

In recent years, much progress has been made in treating people with WM. A number of newer drugs have been found to work against WM, but few studies have compared them to see which ones are best. Because of this, there is no single standard treatment for all patients.

Who treats Waldenstrom macroglobulinemia?

Based on your treatment options, you might have different types of doctors on your treatment team:

  • A hematologist: a doctor who treats disorders of the blood, including lymphomas such as WM
  • A medical oncologist: a doctor who treats cancer with chemotherapy and other medicines
  • A radiation oncologist: a doctor who treats cancer with radiation therapy

Many other specialists might be part of your treatment team as well, including physician assistants (PAs), nurse practitioners (NPs), nurses, nutrition specialists, social workers, and other health professionals.?

Making treatment decisions

It’s important to discuss all treatment options, including their goals and possible side effects, with your doctors to help make the decision that best fits your needs. You may feel that you need to make a decision quickly, but it’s important to give yourself time to absorb the information you have learned. Ask your cancer care team questions.?

If time permits, it is often a good idea to seek a second opinion, particularly for a rare condition such as Waldenstrom macroglobulinemia. A second opinion may give you more information and help you feel more confident about the treatment plan you choose.

Thinking about taking part in a clinical trial

Clinical trials?are carefully controlled research studies that are done to get a closer look at promising new treatments or procedures. Clinical trials are one way to get state-of-the art cancer treatment. In some cases they may be the only way to get access to newer treatments. They are also the best way for doctors to learn better methods to treat cancer.?

If you would like to learn more about clinical trials that might be right for you, start by asking your doctor if your clinic or hospital conducts clinical trials.?

Considering complementary and alternative methods

You may hear about alternative or complementary methods to relieve symptoms or treat your cancer that your doctors haven’t mentioned. These methods can include vitamins, herbs, and special diets, or other methods such as acupuncture or massage, to name a few.

Complementary methods are treatments that are used along with your regular medical care. Alternative treatments are used instead of standard medical treatment. Although some of these methods might be helpful in relieving symptoms or helping you feel better, many have not been proven to work. Some might even be harmful.

Be sure to talk to your cancer care team about any method you are thinking about using. They can help you learn what is known (or not known) about the method, which can help you make an informed decision.?

Help getting through cancer treatment

People with cancer need support and information, no matter what stage of illness they may be in. Knowing all of your options and finding the resources you need will help you make informed decisions about your care.

Whether you are thinking about treatment, getting treatment, or not being treated at all, you can still get supportive care to help with pain or other symptoms. Communicating with your cancer care team is important so you understand your diagnosis, what treatment is recommended, and ways to maintain or improve your quality of life.?

Different types of programs and support services may be helpful, and they can be an important part of your care. These might include nursing or social work services, financial aid, nutritional advice, rehab, or spiritual help.

The American Cancer Society also has programs and services - including rides to treatment,? lodging, and more - to help you get through treatment.?Call our Cancer Knowledge Hub at 1-800-227-2345 and speak with one of our caring, trained cancer helpline specialists. Or, if you prefer, you can use our chat feature on cancer.org to connect with one of our specialists.

Choosing to stop treatment or choosing no treatment at all

For some people, when treatments have been tried and are no longer controlling the cancer, it could be time to weigh the benefits and risks of continuing to try new treatments. Whether or not you continue treatment, there are still things you can do to help maintain or improve your quality of life.

Some people, especially if the cancer is advanced, might not want to be treated at all. There are many reasons you might decide not to get cancer treatment, but it’s important to talk to your doctors as you make that decision. Remember that even if you choose not to treat the cancer, you can still get supportive care to help with pain or other symptoms.

The treatment information given here is not official policy of the American Cancer Society and is not intended as medical advice to replace the expertise and judgment of your cancer care team. It is intended to help you and your family make informed decisions, together with your doctor. Your doctor may have reasons for suggesting a treatment plan different from these general treatment options. Don't hesitate to ask your cancer care team any questions you may have about your treatment options.

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